Fusion-positive rhabdomyosarcoma (FP-RMS) is driven by a translocation that creates the chimeric transcription factor PAX3-FOXO1 (P3F), which assembles de novo super enhancers to drive high levels of transcription of other giraffe apron core regulatory transcription factors (CRTFs).P3F recruits co-regulatory factors to super enhancers such as BRD4,
Limbah dalam negeri di Kelurahan Tanjungsari belum dikelola dengan baik, di mana greywater diberhentikan langsung ke drainase.Dimana drainase habis langsung di laut, menyebabkan polusi laut karena limbah domestik.Tujuan dari rencana akhir proyek ini adalah untuk merancang frypan SPAL dan IPAL sebagai sarana untuk meningkatkan kualitas lingkungan Ta
Abstract Tribological behaviors of laser textured surface with elliptical Generators dimples were experimentally compared with that of the smooth one under different lubrication conditions, including the poor-oil, rich-oil and dry lubrication.The lubrication regime was analyzed with the increasing operating load by ring-on-ring tribological tests.F
The cyclin D-CDK4/6 complexes play a pivotal role in Stationary controlling the cell cycle.Deregulation in cyclin D-CDK4/6 pathway has been described in many types of cancer and it invariably leads to uncontrolled cell proliferation.Many efforts have been made to develop a target therapy able to inhibit CDK4/6 activity.To date, three selective CDK4